Clarithromycin significantly increases linezolid serum concentrations.
نویسندگان
چکیده
منابع مشابه
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients.
The use of linezolid for the treatment of multidrug-resistant tuberculosis is limited by dose- and time-dependent toxicity. Recently, we reported a case of pharmacokinetic drug-drug interaction between linezolid and clarithromycin that resulted in increased linezolid exposure. The aim of this prospective pharmacokinetic study is to quantify the effect of clarithromycin on the exposure of linezo...
متن کاملIn vitro synergy between linezolid and clarithromycin against Mycobacterium tuberculosis.
Approximately 3% of new tuberculosis cases worldwide represent multidrug-resistant tuberculosis (MDRTB) [1]. In these MDR-TB cases, resistance of Mycobacterium tuberculosis to the otherwise effective rifampicin and isoniazid forces clinicians to diverge to other antimicrobial agents. Such treatment options include the World Health Organization (WHO) group 5 drugs linezolid and clarithromycin [1...
متن کاملClinical validation of the analysis of linezolid and clarithromycin in oral fluid of patients with multidrug-resistant tuberculosis.
Linezolid plays an increasingly important role in the treatment of multidrug-resistant tuberculosis (MDR-TB). However, patients should be carefully monitored due to time- and dose-dependent toxicity. Clarithromycin plays a more modest role. Therapeutic drug monitoring may contribute to assessment of treatment regimens, helping to reduce toxicity while maintaining adequate drug exposure. Oral fl...
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Date last updated: October, 2015. 4 Bolhuis MS, van Altena R, van Soolingen D, et al. Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients. Eur Respir J 2013; 42: 1614–1621. 5 Gebhart BC, Barker BC, Markewitz BA. Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin. Pharmacotherapy 2007; 27: 476–479. 6 Gand...
متن کاملSusceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones.
The susceptibility pattern of Mycobacterium marinum was determined. Quinupristin-dalfopristin and telithromycin were less active than clarithromycin. Linezolid showed good antimicrobial activity at clinically achievable concentrations. Gatifloxacin, levofloxacin, and moxifloxacin displayed activities similar to those of ciprofloxacin. Gemifloxacin was less active. The Etest method showed variab...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 54 12 شماره
صفحات -
تاریخ انتشار 2010